The present investigation highlights the formulation, optimization and evaluation of gastroretentive effervescent floating tablets of captopril employing Hibiscus rosa sinensis gum and other polymers like HPMC K4M and HPMC K15M. Captopril, an ACE inhibitor widely used in the treatment of hypertension. Though several floating matrix formers are available, there is a continuous need in the development of novel floating matrix formers which are safe, biocompatible and cost effective. In this regard, present study mainly focussed on the isolation, characterization and evaluation of Hibiscus rosa sinensis gum as a floating matrix former in the formulation of gastroretentive effervescent floating matrix tablets. In order to optimize the concentration of Hibiscus rosa sinensis gum as floating matrix former, 23 factorial design was employed. Formulation was optimized on the basis of floating lag time and T50. The prepared floating tablets were subjected to evaluation for physical characters like hardness, friability, drug content and uniformity, floating lag time, floating time and in-vitro drug release studies. The dissolution data was fitted to kinetic modelling. The optimized formulation followed zero order release model and showed non-fickian diffusion mechanism. The study reveals that concentration of 40% of the Hibiscus rosa sinensis gum can be used as floating matrix former in the formulation of gastroretentive effervescent floating tablets.
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